Keratinization

Keratinization and its disorders.

Keratins are a diverse group of structural proteins that form the intermediate filament network responsible for maintaining the structural integrity of keratinocytes. In humans, there are around 30 keratin families divided into two groups, namely, acidic and basic keratins, which are arranged in pairs. They are expressed in a highly specific pattern related to the epithelial type and stage of c...

Sulfur-containing Proteins and Epidermal Keratinization

Sites of synthesis of sulfur-containing protein in keratinizing epithelium have been studied by radioautography after injection of sulfur-labeled cystine. Bern et al. (3) demonstrated concentration of silver grains immediately below the cornified layer, suggesting that much of sulfur is added at the final stages of keratinization as observed in hair. In contrast, B6langer (4) reported that prot...

Keratinization Disorders and Genetic Aspects in Palmar and Plantar Keratodermas.

Palmoplantar keratoderma (PPK) is a heterogeneous group of hereditary and acquired disorders characterized by abnormal thickening of the palms and soles. There are three clinical patterns: diffuse, focal, and punctuate. Palmoplantar keratodermas can be divided into the following functional subgroups: disturbed gene functions in structural proteins (keratins), cornified envelope (loricrin, trans...

The Differentiation and Keratinization of Epithelium in Vitro

The organization, or, according to Drew, differentiation, of epithelial cells grown in vitro is not due to a specific influence of the associated connective tissue. It occurs in all old pure cultures of epithelium, when the tissue fragment becomes thick and suffers from lack of oxygen and nourishment. Under the same circumstances, keratinization occurs in cultures of epithelium.

Epidermal keratinization: localization of isotopically labeled amino acids.